When assessing for adverse effects of fludrocortisone (Florinef), the nurse would monitor for signs of which condition?

When assessing for adverse effects of fludrocortisone (Florinef), the nurse would monitor for signs of which condition?

• A. Hypokalemia
• B. Hypovolemia
• C. Hyponatremia
• D. Hypercalcemia

Answer: (A)

Fludrocortisone acts as a mineralocorticoid, promoting sodium and water reabsorption in the kidneys while increasing potassium excretion. This potassium loss leads to hypokalemia, which is why monitoring potassium levels and signs of low potassium (such as muscle weakness, fatigue, cramps, or cardiac arrhythmias) is essential. Hyponatremia would be unlikely because sodium tends to be retained, not lost, with this drug. Hypercalcemia is not a typical adverse effect of fludrocortisone, and hypovolemia would not be expected due to the drug’s tendency to expand volume through sodium and water retention.

Fludrocortisone acts as a mineralocorticoid, promoting sodium and water reabsorption in the kidneys while increasing potassium excretion. This potassium loss leads to hypokalemia, which is why monitoring potassium levels and signs of low potassium (such as muscle weakness, fatigue, cramps, or cardiac arrhythmias) is essential.

Hyponatremia would be unlikely because sodium tends to be retained, not lost, with this drug. Hypercalcemia is not a typical adverse effect of fludrocortisone, and hypovolemia would not be expected due to the drug’s tendency to expand volume through sodium and water retention.