Which adverse effect is associated with aminoglutethimide therapy?

Which adverse effect is associated with aminoglutethimide therapy?

• A. Constipation
• B. Dizziness
• C. Anorexia
• D. Hypotension

Answer: (B)

Dizziness is a common central nervous system–related adverse effect of aminoglutethimide. This drug blocks enzymes involved in steroid synthesis, including aromatase and desmolase, and can cross into the CNS, leading to mild CNS depression or vestibular effects. That makes dizziness a typical and notable adverse reaction to monitor. Constipation, anorexia, and hypotension are less characteristic or not as consistently reported with aminoglutethimide. If dizziness occurs, assess safety (especially with standing) and counsel the patient to rise slowly and report persistent symptoms.

Dizziness is a common central nervous system–related adverse effect of aminoglutethimide. This drug blocks enzymes involved in steroid synthesis, including aromatase and desmolase, and can cross into the CNS, leading to mild CNS depression or vestibular effects. That makes dizziness a typical and notable adverse reaction to monitor.

Constipation, anorexia, and hypotension are less characteristic or not as consistently reported with aminoglutethimide. If dizziness occurs, assess safety (especially with standing) and counsel the patient to rise slowly and report persistent symptoms.